Clinical Pharmacology & Therapeutics

1. Impaired Drug Metabolism Caused by Compound Heterozygous Loss‐of‐Function Variants in CYP3A4: A Case Report

   Clinical Pharmacology &Therapeutics, EarlyView.

2. Prospective DDI Risk Assessment of Vicasinabin with PBPK Modeling by Integrating In Vitro Data

   Clinical Pharmacology &Therapeutics, EarlyView.

3. US Food and Drug Administration's Advancing Real‐World Evidence Program: Initial Experience

   Clinical Pharmacology &Therapeutics, EarlyView.

4. Estimating the Frequency of False‐Negative Pharmacogenetic Test Results by Self‐Reported Ancestry

   Clinical Pharmacology &Therapeutics, EarlyView.

5. Real‐World Evidence in New Drug and Biologics License Application Approvals During Fiscal Years 2020–2022

   Clinical Pharmacology &Therapeutics, EarlyView.

6. Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account

   Clinical Pharmacology &Therapeutics, EarlyView.

7. The Drug Titration Paradox Updated and Reinterpreted: With Perfect Titration, Dose and Effect Will Be Uncorrelated

   Clinical Pharmacology &Therapeutics, EarlyView.

8. Oncology Dose Optimization: Tailored Approaches to Different Molecular Classes

   Clinical Pharmacology &Therapeutics, EarlyView.

9. ESR1 Variants and Subcontinental Genomic Ancestry: Insights from the 1000 Genomes Project and Native American Populations

   Clinical Pharmacology &Therapeutics, EarlyView.

10. Innovations and Best Practices for Therapeutic Development in Pediatric Rare Diseases: A Model‐Informed Drug Development Perspective

    Clinical Pharmacology &Therapeutics, EarlyView.

11. Supplementing Single‐Arm Trials with External Control Arms—Evaluation of German Real‐World Data

    Clinical Pharmacology &Therapeutics, EarlyView.

12. Prenatal and Early Childhood Exposure to Antibiotics or Gastric Acid Inhibitors and Increased Risk of Epilepsy: A Nationwide Population‐Based Study

    Clinical Pharmacology &Therapeutics, EarlyView.

13. Clinical Benefit, Trials, and Regulatory Approval of Oncology Indications Under Multiple Expedited Programs for Drug Marketing in China, 2018–2024

    Clinical Pharmacology &Therapeutics, EarlyView.

14. Emergence of Small Nucleic Acids as Drugs in Precision Medicine

    Clinical Pharmacology &Therapeutics, EarlyView.

15. In this Issue

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1157-1158, May 2025.

16. Optimal Drug, Optimal Dose, or Both in the Pharmacological Treatment of Neonatal Opioid Withdrawal Syndrome?

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1182-1184, May 2025.

17. Highlighted Articles

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1162-1163, May 2025.

18. ASCPT News

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1164-1170, May 2025.

19. MRI Provides New Insights Into the Pharmacologic Mechanism of Bisacodyl: A Blueprint for Understanding Intestinal Drug Mechanisms

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1159-1161, May 2025.

20. Issue Information

    Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1149-1154, May 2025.