American journal of health-system pharmacy : AJHP

1. Interventions to improve emergency department postintubation sedation and analgesia: a systematic review

   CONCLUSION: There is a small- to moderate-sized body of evidence to guide interventions to improve ED postintubation sedation and analgesia that is limited by heterogeneous outcome definitions and poor reporting of methods. Future work should include consistent, patient-centered outcome selection and rigorous reporting in adherence to guidelines on education and implementation research.

2. Cardiovascular outcomes of glucagon-like peptide-1 receptor agonists: A systematic review

   CONCLUSION: These data support the use of GLP1RAs to lower MACE in patients with T2D. A cardiovascular benefit with GLP1RA therapy was also observed in 2 additional patient populations: those with overweight/obesity and ASCVD but without T2D and those with obesity and HFpEF with or without T2D.

3. Efficacy and risks of psychedelics in the treatment of posttraumatic stress disorder: A systematic review

   CONCLUSION: MDMA and ketamine IV currently have the greatest support in the literature for efficacy in PTSD. Studies suggest treatment with these agents under supervision may lead to improvements in PTSD symptoms, with the medications being generally well tolerated. However, caution should be used when interpreting study results due to limitations such as treatment expectancy effect and the potential for inadequate blinding. Randomized controlled studies of other psychedelics (eg, psilocybin,...